| Gene Symbol | PDP1 |
| Full Name | Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1 |
| Chromosome | 8q22.1 |
| Protein Type | Ser/Thr protein phosphatase |
| Primary Expression | Brain (high), heart, skeletal muscle, liver |
| Molecular Weight | 71 kDa |
| Amino Acids | 625 aa |
| Exons | 19 |
| UniProt ID | [Q9N2I8](https://www.uniprot.org/uniprot/Q9N2I8) |
| Ensembl ID | ENSG00000153540 |
| GeneCards | PDP1 |
| Human Protein Atlas | PDP1 |
| PDP1L1 | A testis-specific isoform with distinct regulatory properties |
| Calcium signaling | Activity-induced calcium influx can activate calmodulin-dependent pathways that influence PDP1 |
| Metabolic feedback | ATP/ADP ratios, NADH/NAD+ ratios, and pyruvate levels all affect PDC activity |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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