| Tremor | Predominantly resting tremor, often with postural component |
| Muscle rigidity | Cogwheel rigidity characteristic of parkinsonism |
| Bradykinesia | Progressive slowing of voluntary movements |
| Postural instability | Impaired balance and falls |
| Gait difficulties | Shuffling gait, freezing of gait |
| Sleep disorders | Severe insomnia, sleep inversion, REM sleep behavior disorder |
| Oculogyric crises | Painful episodic upward (or lateral) gaze lasting minutes to hours |
| Psychiatric manifestations | Anxiety, depression, psychosis, personality changes |
| Autonomic dysfunction | Orthostatic hypotension, urinary incontinence, constipation |
| Cognitive impairment | Executive dysfunction, memory deficits, dementia in advanced stages |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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