| Gene Symbol | ABCAC4 |
| Aliases | ABCAC4PROTEIN |
| Function | ABCA4 (ATP-binding cassette transporter A4) is a 2,273-amino acid protein belonging to the ABC transporter family, primarily expressed in photoreceptor cells and retinal pigment epithelium (RPE)[@a... |
| Subcellular Localization | </b></td><td>Outer segment discs of photoreceptor cells, retinal pigment epithelium</td></tr> |
| GeneCards | ABCAC4 |
| Human Protein Atlas | ABCAC4 |
| Two transmembrane domains (TMD) | 12 transmembrane helices spanning the disc membrane |
| Extracellular loops | Form the substrate entry site for retinoid compounds |
| Intracellular loops | Connect TMDs and contain regulatory elements |
| Two nucleotide-binding domains (NBD) | ATP-binding cassettes with Walker A/B motifs |
| ABC signature (C-loop) | Contains the conserved LSGGQ motif |
| H-loop (switch region) | Contains the catalytic histidine |
| N-terminal extracellular domain | Unique to the ABCA subfamily |
| Coupling helix | Connects TMD to NBD for conformational transmission |
| Dimerization | The protein forms a functional homodimer in the membrane |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |