| Gene Symbol | ADENYLATECYCLASE6 |
| Aliases | ADENYLATECYCLASE6 |
| 12 Transmembrane Helices | Six transmembrane segments in the N-terminal and six in the C-terminal regions |
| Cytosolic Catalytic Domains | C1a and C2a cytoplasmic domains that form the catalytic core |
| Calcium-Binding Site | Unique C-terminal region responsible for calcium inhibition |
| G Protein-Binding Regions | Sites for interaction with Gsα and Giα subunits |
| Primary reaction | ATP → cAMP + PPi |
| K_m for ATP | ~100 μM |
| V_max | Comparable to other AC isoforms |
| Gsα activation | Stimulates AC6 activity 3-5 fold |
| Giα inhibition | Reduces AC6 activity by 30-50% |
| Gβγ complex | Modulates AC6 depending on cellular context |
| Forskolin | Direct activator of catalytic domains |
| Cerebellum | Purkinje cells show prominent AC6 |
| Basal ganglia | Moderate expression in striatum |
| Brainstem | Variable expression patterns |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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