protein 640 words KG: ALPHALIDURONIDASE 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Alpha-L-iduronidase Protein

🔬 Protein Info
Gene SymbolALPHA-L-IDURONIDASE
AliasesALPHALIDURONIDASE
Chromosome4p16.3.
Functionis a lysosomal hydrolase encoded by the IDUA gene
Molecular Weight76 kDa
IDUA geneThe genomic locus encoding alpha-L-iduronidase
Mucopolysaccharidosis type IThe genetic disorder resulting from IDUA deficiency
Heparan sulfatePrimary substrate of alpha-L-iduronidase
Lysosomal storage disordersRelated group of enzymatic deficiency diseases
LaronidaseRecombinant therapeutic form of the enzyme
Associated DiseasesNeurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in