| Gene Symbol | ANNEXINA11 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ## Role in Disease
### Amyotrophic Lateral SALS (ALS)
ANXA11 mutations cause a |
| Molecular Weight | 54 kDa |
| GeneCards | ANNEXINA11 |
| Human Protein Atlas | ANNEXINA11 |
| Membrane organization | Binds to phospholipid membranes in a calcium-dependent manner |
| Vesicle trafficking | Regulates exocytosis and endocytosis |
| [Autophagy](/entities/autophagy) | Involved in autophagosome formation and lysosomal function |
| [TDP-43](/proteins/tdp-43) binding | Interacts with TDP-43 and influences its localization |
| Calcium dysregulation | Impaired calcium binding affects neuronal function |
| TDP-43 mislocalization | Disrupted interaction with TDP-43 leads to nuclear loss |
| Autophagy defects | Impaired lysosomal function and protein clearance |
| [Tau](/proteins/tau) pathology | Potential involvement in tau aggregation or clearance |
| Brainstem vulnerability | Selective susceptibility of brainstem neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |