| Gene Symbol | ATAXIN2 |
| Aliases | ATAXIN2PROTEIN |
| Protein Family | Ataxin-2 family, RNA-binding proteins |
| Function | is a cytoplasmic RNA-binding protein encoded by the ATXN2 gene that plays critical roles in RNA metabolism, stress granule dynamics, and translational control. |
| Molecular Weight | 140 kDa |
| Amino Acids | 1313 aa |
| UniProt ID | Q99700 |
| GeneCards | ATAXIN2 |
| Human Protein Atlas | ATAXIN2 |
| PolyQ tract | Variable length (normally 22-23 repeats); pathogenic when expanded |
| Lsm domain | Facilitates RNA binding and protein-protein interactions |
| PAM2 motif | Binds to PABPC1 (poly(A)-binding protein), linking ataxin-2 to mRNA regulation |
| Prion-like domain | Promotes aggregation and stress granule formation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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