| Gene Symbol | ATLASTIN1 |
| Aliases | ATLASTIN1PROTEIN |
| Protein Family | Atlastin/Sey1p GTPase family |
| Function | Atlastin-1 (ATL1), also known as SPG3A or HSpL1, is a membrane-anchored GTPase that plays essential roles in endoplasmic reticulum (ER) morphology, membrane trafficking, and neuronal development. |
| Primary Expression | Neurons (corticospinal tract), all tissues |
| Subcellular Localization | Endoplasmic reticulum membrane |
| Molecular Weight | ~56 kDa |
| UniProt ID | Q9Y2K2 |
| GeneCards | ATLASTIN1 |
| Human Protein Atlas | ATLASTIN1 |
| Protein Name | Atlastin-1 (ATL1) |
| Gene | ATL1 |
| Mutation Type | Severity |
| GTPase domain (R239C) | Early-onset, severe |
| Dimerization (R495Q) | Adult-onset |
| Databases | GeneCardsNCBI GeneHPASTRING |