| Gene Symbol | BAG |
| Full Name | 4 Protein |
| Aliases | BAG4PROTEIN |
| Function | BAG-4 regulates the ATPase activity of Hsp70 and Hsc70 through its BAG domain. By binding to the EEVD motif at the C-terminus of Hsp70, BAG-4 acts as a nucleotide exchange factor, facilitating the ... |
| Subcellular Localization | Signals (NLS)**: Multiple NLS sequences are present in certain isoforms, allowin |
| GeneCards | BAG |
| Human Protein Atlas | BAG |
| Nuclear Localization Signals (NLS) | Multiple NLS sequences are present in certain isoforms, allowing for nuclear translocation and potential roles in transcriptional regulation. |
| Protein Interaction Motifs | The N-terminal region contains multiple motifs that enable interaction with various client proteins, including death domain-containing proteins like TNF receptor 1 and Fas. |
| Oligomerization Capacity | BAG-4 can form homooligomers, which may enhance its ability to coordinate multi-protein complexes involved in apoptosis regulation. |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!