protein 897 words KG: C1QSUBUNITA 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Complement C1q Subunit A Protein

🔬 Protein Info
Gene SymbolC1QSUBUNITA
Full NameComplement C1q Subunit A
Protein FamilyC1q family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain by microglia and neurons and plays important roles in synaptic pruning, phagocytosis, and neuroinflammation
Subcellular LocalizationSecreted, plasma membrane
Molecular Weight26 kDa (subunit), 460 kDa (complex)
UniProt IDP02787
GeneCardsC1QSUBUNITA
Human Protein AtlasC1QSUBUNITA
Protein NameComplement C1q Subunit A
GeneC1QA
Drug/ApproachTarget
Anti-C1q antibodiesC1q
C1s inhibitorsC1s
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Astrocyte-Microglia Communication Rebalancing via Cytokine M
Score: 0.49
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.40
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (14)

What are the specific molecular mechanisms by which C1Q comp
neuroinflammation · failed
How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in