| Gene Symbol | CALMODULIN |
| Aliases | CALMODULINPROTEIN |
| Pathways | Mtor, Blood-Brain Barrier |
| GeneCards | CALMODULIN |
| Human Protein Atlas | CALMODULIN |
| N-terminal domain | Contains EF-hands 1-2 |
| C-terminal domain | Contains EF-hands 3-4 |
| Central linker | Flexible helix allowing domain movement |
| Calcium dysregulation | AD is associated with altered calcium homeostasis; calmodulin-mediated signaling is affected by amyloid-beta and tau pathology |
| Calcineurin/NFAT pathway | Amyloid-beta reduces calcineurin activity, disrupting NFAT-mediated gene transcription and synaptic plasticity |
| CaMKII dysfunction | Changes in CaMKII signaling contribute to synaptic loss and memory impairment |
| Dopaminergic neuron vulnerability | Calcium influx through L-type channels is elevated in substantia nigra pars compacta neurons; calmodulin modulates these channels |
| Alpha-synuclein aggregation | Calmodulin can bind to alpha-synuclein and influence its aggregation properties |
| Excitotoxicity | Calmodulin regulates glutamate receptors; dysregulation may contribute to excitotoxic cell death |
| Transcriptional dysregulation | Calmodulin-calcineurin-NFAT signaling is impaired in HD |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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