| Gene Symbol | CCNE2 |
| Aliases | CCNE2PROTEIN |
| Function | Cyclin E2 is a member of the cyclin family (404 amino acids) characterized by two conserved cyclin boxes that mediate binding to CDK partners. CCNE2 forms active kinase complexes primarily with CDK... |
| Subcellular Localization | </span><span class="infobox-value">Nucleus, cytoplasm</span></div> |
| GeneCards | CCNE2 |
| Human Protein Atlas | CCNE2 |
| Cell cycle regulation | Controls G1/S phase transition by phosphorylating substrates including Rb, p107, p130, and NPAT |
| DNA replication | Regulates origin firing through interaction with MCM proteins and Cdc6 |
| Centrosome duplication | Essential for proper centrosome copy number regulation |
| Cellular differentiation | Involved in differentiation programs, including neuronal differentiation |
| Alzheimer's Disease | CCNE2 expression is elevated in AD brain, promoting aberrant cell cycle re-entry in neurons. Cyclin E/CDK2 hyperactivity phosphorylates tau and contributes to neurofibrillary pathology. |
| DNA damage response | CCNE2-mediated cell cycle dysregulation increases neuronal vulnerability to DNA damage |
| Neuronal development | Proper CCNE2 regulation is essential for neural progenitor proliferation and differentiation |
| Roscovitine | CDK inhibitor in clinical trials for various indications |
| CVT-313 | Specific CDK2 inhibitor, preclinical |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |