| Gene Symbol | CENPJ |
| Aliases | Centromere Protein J |
| Chromosome | 13q12.2. |
| Function | CENPJ (Centromere Protein J), also known as CPAP (Centromere Protein N), is a crucial centrosomal protein essential for centriole duplication, centrosome maturation, and proper mitotic spindle form... |
| Molecular Weight | 136 kDa |
| GeneCards | CENPJ |
| Human Protein Atlas | CENPJ |
| N-terminal domain | Contains the ST (S/T) motif that mediates protein-protein interactions with centriolar components |
| Central coiled-coil regions | Facilitate protein oligomerization and complex formation with other centriolar proteins including SAS-4 (in Drosophila) and STIL |
| C-terminal domains | Contain regulatory motifs that control protein stability and function |
| Severe microcephaly | Head circumference >3 standard deviations below the mean |
| Reduced cortical volume | Markedly reduced brain size, particularly affecting the cerebral cortex |
| Developmental delay | Variable intellectual disability depending on mutation severity |
| Seizures | Some patients present with epileptic episodes |
| Normal facial features | Unlike other microcephaly syndromes, facial dysmorphism is typically mild |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |