| Gene Symbol | CERNUNNOSX1 |
| Aliases | CERNUNNOSX1PROTEIN |
| Function | The protein forms a homodimer or oligomer that bridges DNA ends during the repair process. |
| Subcellular Localization | signal (NLS)**:确保蛋白质定位到细胞核 The protein forms a homodimer or oligomer that bridg |
| Molecular Weight | 65 kDa |
| Amino Acids | 571 aa |
| GeneCards | CERNUNNOSX1 |
| Human Protein Atlas | CERNUNNOSX1 |
| N-terminal region | Contains motifs involved in protein-protein interactions with other NHEJ factors |
| Central domain | Binds DNA double-strand breaks directly |
| C-terminal region | Interacts with Ku70/Ku80 heterodimer and DNA-PKcs |
| Nuclear localization signal (NLS) | 确保蛋白质定位到细胞核 |
| Alzheimer's Disease (AD) | Increased DNA damage markers in neurons, with impaired repair capacity |
| Parkinson's Disease (PD) | Oxidative DNA damage accumulates in substantia nigra neurons |
| Amyotrophic Lateral Sclerosis (ALS) | DNA repair deficits contribute to motor neuron degeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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