| Gene Symbol | CERULOPLASMIN |
| Aliases | CERULOPLASMINPROTEIN |
| Function | Ceruloplasmin is a multi-copper ferroxidase essential for systemic and brain iron metabolism |
| Subcellular Localization | </b></td><td>Secreted, plasma; also membrane-associated</td></tr> |
| Molecular Weight | 151 kDa |
| Amino Acids | 1046 aa |
| GeneCards | CERULOPLASMIN |
| Human Protein Atlas | CERULOPLASMIN |
| Multicopper oxidase domain | Contains 6 tightly bound copper atoms essential for ferroxidase activity |
| Three major domains | Each with distinct structural roles |
| Glycosylation | Extensive N-linked glycosylation (25% carbohydrate by weight) |
| Active sites | Separate copper-binding sites for electron transfer and substrate oxidation |
| Iron metabolism | Ferroxidase activity converts Fe²⁺ to Fe³⁺ for transferrin binding |
| Copper transport | Carries >95% of circulating copper |
| Antioxidant defense | Scavenges free radicals, inhibits iron-induced oxidation |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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