| Gene Symbol | CHCHD6 |
| Aliases | CHCHD6PROTEINNEW |
| Chromosome | 3p24.3. |
| Function | CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6) is a mitochondrial protein encoded by the CHCHD6 gene located on chromosome 3p24.3. |
| Subcellular Localization | </strong></td><td>Mitochondria (inner membrane)</td></tr> [@bannwarth2014] |
| Molecular Weight | Approximately 29 kDa |
| GeneCards | CHCHD6 |
| Human Protein Atlas | CHCHD6 |
| Twin CX9C Motifs | The protein contains two CX9C sequences within its CHCH domains, which coordinate zinc ions and stabilize the protein fold [1] |
| Coiled-Coil Regions | N-terminal and C-terminal coiled-coil domains facilitate dimerization with other CHCH domain proteins |
| Inner Membrane Anchor | A hydrophobic segment targets CHCHD6 to the mitochondrial inner membrane |
| Oligomerization | Forms homodimers and heterodimers with related proteins like CHCHD2, CHCHD3, and CHCHD10 |
| Electron Transfer | Facilitates efficient electron flow through the respiratory chain |
| ATP Synthesis | Couples oxidative phosphorylation to ATP production |
| Mitochondrial Membrane Potential | Maintains the electrochemical gradient essential for ATP synthesis |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |