protein 888 words KG: CLCN4PROTEIN
Contents

ClC-4 Chloride Channel

🔬 Protein Info
Gene SymbolCLCN4PROTEIN
Full NameClC-4 Chloride Channel
ChromosomeXp22.2
Protein FamilyCLC chloride channel family
Protein TypeChannel
Functionis a voltage-gated chloride channel encoded by the CLCN4 gene.
Primary Expressionmultiple tissues:
Molecular Weight~85 kDa
Exons12
UniProt IDP51801
GeneCardsCLCN4PROTEIN
Human Protein AtlasCLCN4PROTEIN
E166" gatea conserved glutamate residue that acts as a gating mechanism
BrainNeuronal endosomes, particularly in hippocampus and cerebral cortex
KidneyProximal tubule epithelial cells
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (6)

Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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