protein 888 words KG: CLCN4PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ClC-4 Chloride Channel

🔬 Protein Info
Gene SymbolCLCN4PROTEIN
Full NameClC-4 Chloride Channel
ChromosomeXp22.2
Protein FamilyCLC chloride channel family
Protein TypeChannel
Functionis a voltage-gated chloride channel encoded by the CLCN4 gene.
Primary Expressionmultiple tissues:
Subcellular LocalizationEndosomes, plasma membrane
Molecular Weight~85 kDa
Exons12
UniProt IDP51801
GeneCardsCLCN4PROTEIN
Human Protein AtlasCLCN4PROTEIN
Protein NameClC-4 Chloride Channel
GeneCLCN4
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in