protein 1,369 words KG: CLCN6PROTEIN 2026-03-29
kind:proteinsection:proteinsstate:published
Contents

ClC-6 Chloride Channel

🔬 Protein Info
Gene SymbolCLCN6PROTEIN
Full NameClC-6 Chloride Channel
Protein FamilyCLC chloride channel family
Protein TypeChannel
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), peripheral tissues
Subcellular LocalizationLate endosomes, lysosomes (predicted)
Molecular Weight~87 kDa
UniProt IDP51796
GeneCardsCLCN6PROTEIN
Human Protein AtlasCLCN6PROTEIN
Protein NameClC-6 Chloride Channel
GeneCLCN6
ChannelLocation
ClC-3Synaptic vesicles
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in