protein 769 words KG: COA6PROTEIN
Contents

COA6 Protein (Cytochrome C Oxidase Assembly Factor 6)

🔬 Protein Info
Gene SymbolCOA6
Full NameCytochrome c Oxidase Assembly Factor 6
AliasesCOA6PROTEIN
Chromosome1q23.3
Functionis a small mitochondrial protein that plays a critical role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain.
Subcellular LocalizationMitochondrial inner membrane
Molecular WeightApproximately 12 kDa
Amino Acids87 aa
Exons3
GeneCardsCOA6
Human Protein AtlasCOA6
TopologyIntermembrane space-facing protein with single transmembrane anchor
MotifTwin Cx9C motif characteristic of mitochondrial intermembrane space proteins
Electron TransportFinal step of the electron transport chain
ATP SynthesisCoupling to oxidative phosphorylation
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (4)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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