| Gene Symbol | COMPLEXIN1 |
| Function | is a small synaptic protein (134 amino acids, ~15 kDa) that critically regulates neurotransmitter release by modulating SNARE complex assembly and fusion kinetics. |
| Subcellular Localization | </th><td>Presynaptic terminals, synaptic vesicles</td></tr> |
| Molecular Weight | 16 kDa |
| Amino Acids | 136 aa |
| GeneCards | COMPLEXIN1 |
| Human Protein Atlas | COMPLEXIN1 |
| N-terminal domain (aa 1-50) | Contains the "activator" region that promotes fusion by facilitating SNARE complex zippering. This domain penetrates the SNARE bundle and accelerates the final stages of fusion [@lin2011]. |
| Central α-helical domain (aa 51-100) | The core SNARE-interacting region that binds to assembled SNARE complexes. This domain contains two α-helices that wrap around the SNARE bundle, stabilizing the fusion-competent state [@rizo2019]. |
| C-terminal domain (aa 101-134) | The "clamp" region that prevents spontaneous fusion by competing with synaptotagmin for SNARE binding. This domain anchors complexin to the synaptic vesicle membrane [@tang2006]. |
| Docking | May contribute to the proper positioning of vesicles at active zones |
| Priming | Stabilizes the SNARE complex in a fusion-competent state |
| Fusion triggering | Works in concert with synaptotagmin to trigger rapid fusion upon calcium entry |
| Recycling | Facilitates the disassembly and recycling of SNARE components after fusion |
| Synchronous release | Essential for fast, action potential-evoked release through its interaction with synaptotagmin and SNARE complexes [@cho2015]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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