protein 841 words KG: COX20PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

COX20 Protein (Cytochrome C Oxidase Assembly Factor)

🔬 Protein Info
Gene SymbolCOX20
Full NameCOX20 (Cytochrome C Oxidase Assembly Factor)
AliasesCytochrome c Oxidase Assembly Factor 20, Cytochrome C Oxidase Assembly Factor
Chromosome1p31.3
Protein TypeProtein
Functionis a nuclear-encoded mitochondrial protein that plays an indispensable role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain.
Primary ExpressionHigh in cerebellum, inner ear, heart, skeletal muscle
Subcellular Localization**Mitochondrial inner membrane**: Integral membrane protein
Molecular Weight22 kDa
Amino Acids198 aa
UniProt IDQ9Y4Y6
NCBI Gene ID91574
Ensembl IDENSG00000173391
GeneCardsCOX20
Human Protein AtlasCOX20
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in