| Gene Symbol | DAOA |
| Aliases | DAOAPROTEIN |
| Function | The reaction proceeds through a reductive half-reaction where the substrate reduces the flavin, followed by an oxidative half-reaction where the reduced flavin is reoxidized by molecular oxygen, pr... |
| Subcellular Localization | ** | Peroxisomes | |
| Molecular Weight | 40 kDa |
| Amino Acids | 200 aa |
| GeneCards | DAOA |
| Human Protein Atlas | DAOA |
| Peroxisomal targeting signal | The C-terminal region contains the tripeptide SKL (serine-lysine-leucine) peroxisomal targeting signal (PTS1), which directs the enzyme to peroxisomes. |
| Dimerization interface | DAO forms functional homodimers, with each monomer capable of independently binding FAD and substrate. |
| D-serine | Primary physiological substrate in the brain |
| D-alanine | Significant substrate in peripheral tissues |
| D-aspartate | Important in endocrine tissues |
| D-phenylalanine | Metabolized at lower rates |
| D-serine regulation | D-serine is a major NMDA receptor co-agonist, and DAO controls its extracellular levels |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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