protein 830 words KG: DNAJC3PROTEIN
Contents

DNAJC3 Protein

🔬 Protein Info
Gene SymbolDNAJC3
AliasesDNAJC3PROTEIN
Protein TypeGene
FunctionDNAJC3, also known as P58IPK or ERdj5, is an endoplasmic reticulum (ER)-localized DnaJ chaperone with multiple cellular functions
Primary Expressiontissues with high secretory capacity:
Amino Acids483 aa
UniProt IDQ9Y2H1
Ensembl IDENSG00000137168
GeneCardsDNAJC3
Human Protein AtlasDNAJC3
Protein folding assistanceJ domains recruit BiP/Kar2
Disulfide bond formationPDI-like thioredoxin domain
ER-associated degradation (ERAD)Retro-translocates misfolded proteins
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (4)

SASP-Mediated Complement Cascade Amplification
Score: 0.82
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.