protein 966 words KG: DOCK1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Dedicator of Cytokinesis 1 Protein

🔬 Protein Info
Gene SymbolDOCK1PROTEIN
Full NameDedicator of Cytokinesis 1 Protein
Protein FamilyDOCK family (DOCK-A subfamily)
Functionis a large guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases through its DHR-2 (Docker Homology Region 2) domain[@cote2005].
Primary Expressionpyramidal and interneurons
Subcellular LocalizationCytoplasm, Plasma membrane, Lamellipodia
Molecular Weight215 kDa (1,864 amino acids)
Amino Acids864 aa
UniProt IDQ8IU85
GeneCardsDOCK1PROTEIN
Human Protein AtlasDOCK1PROTEIN
Protein NameDedicator of Cytokinesis 1 Protein
GeneDOCK1
PDB IDs1WP6, 5E34, 5E35
Brain ExpressionHigh in hippocampus, cortex, cerebellum
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph