| Gene Symbol | DDC |
| Aliases | DOPADECARBOXYLASE |
| Chromosome | 7p12.2 |
| Protein Type | Enzyme |
| Function | This is critical for PD treatment, as the efficacy of L-DOPA therapy depends on residual AADC activity in surviving nigrostriatal neurons[@lerner2020]. |
| Primary Expression | the substantia nigra pars compacta (SNc), ventral tegmental area (VTA), locus coeruleus, and raphe nuclei—regions critical for movement control, rewar |
| Molecular Weight | 54 kDa |
| Amino Acids | 466 aa |
| Pathways | NF-kB signaling, circadian regulation, glymphatic clearance, oxidative stress response |
| Ensembl ID | ENSG00000132437 |
| GeneCards | DDC |
| Human Protein Atlas | DDC |
| Agent | Mechanism |
| L-DOPA/Carbidopa | Carbidopa blocks peripheral AADC |
| L-DOPA/Benserazide | Peripheral AADC inhibition |
| Associated Diseases | Alzheimer's disease, Parkinson, Parkinson's Disease, als, alzheimer |
| Known Drugs/Compounds | levodopa |
| Interactions | GBA, LRRK2, MT1, TH, AQP4, APOE |
| SciDEX Hypotheses | Correcting Gut Microbial Dopamine Imbalance to Sup |
| KG Connections | 116 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |