| Gene Symbol | DYNAMIN2 |
| Aliases | DYNAMIN2PROTEIN |
| Function | Dynamin-2 is a large GTPase protein that plays essential roles in membrane trafficking, particularly in clathrin-mediated endocytosis and synaptic vesicle recycling. |
| Subcellular Localization | </span><span class="infobox-value">Plasma Membrane, Cytoplasm, Golgi, Centrosome</span></div> |
| GeneCards | DYNAMIN2 |
| Human Protein Atlas | DYNAMIN2 |
| GTPase Domain | The N-terminal GTPase domain binds and hydrolyzes GTP. Unlike small GTPases, dynamin has a low intrinsic GTPase activity that is dramatically stimulated by assembly. |
| PH Domain | Binds specifically to phosphatidylinositol-4,5-bisphosphate (PIP₂) at the plasma membrane, targeting dynamin to sites of endocytosis. |
| Self-Assembly | Dynamin-2 forms higher-order oligomers (tetramers and helical polymers) that are the active form responsible for membrane fission. |
| PRD Binding | The proline-rich domain interacts with SH3 domain-containing proteins including amphiphysin, endophilins, and syndapins. |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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