| Gene Symbol | DYNAMIN3 |
| Aliases | DYNAMIN3PROTEIN |
| Chromosome | 1p31.3. |
| Function | Dynamin-3 plays essential roles in synaptic plasticity, neurotransmitter release, and neuronal signaling. Research has implicated DNM3 variants in neurodegenerative diseases, making it a potential ... |
| Subcellular Localization | to postsynaptic compartments, where it participates in: - **Synaptic Vesicle Re |
| GeneCards | DYNAMIN3 |
| Human Protein Atlas | DYNAMIN3 |
| GTPase Domain | N-terminal domain (~300 aa) that binds and hydrolyzes GTP, providing the mechanical force for membrane scission |
| Middle Domain | Central region involved in self-assembly and dimerization |
| Pleckstrin Homology (PH) Domain | Binds phosphatidylinositol (4,5)-bisphosphate (PIP2) at the plasma membrane |
| GTPase Effector Domain (GED) | C-terminal region that regulates GTPase activity and interacts with actin |
| Synaptic Vesicle Recycling | Facilitates endocytosis of synaptic vesicles at the presynaptic terminal |
| Dendritic Spine Morphogenesis | Regulates the formation and maintenance of dendritic spines, which are critical for excitatory synaptic transmission |
| Postsynaptic Receptor Trafficking | Involved in the endocytosis and recycling of glutamate receptors, particularly AMPA receptors |
| Actin Cytoskeleton Dynamics | Interacts with the actin cytoskeleton to regulate spine structure and plasticity |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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