protein 1,813 words KG: EFEMP1PROTEIN 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

EFEMP1 Protein

🔬 Protein Info
Gene SymbolEFEMP1
AliasesFibulin-3
Chromosome2p16
FunctionThe protein is encoded by the EFEMP1 gene located on chromosome 2p16, and is expressed in multiple tissues including brain, retina, and vascular endothelium.
Molecular Weight~54-60 kDa (depending on glycosylation)
Amino Acids493 aa
UniProt IDQ12805
GeneCardsEFEMP1
Human Protein AtlasEFEMP1
Protein NameFibulin-3 (EFEMP1)
Length493 amino acids
PDB Structures1BO3, 2J0C, 5VFH
PathwayEffect
NF-κBActivation
MAPK/ERKVariable
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 4 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses