| Gene Symbol | F11R |
| Aliases | F11RPROTEIN |
| Function | The extracellular Ig-like domains form a "head" structure that enables dimerization and adhesion. Crystal structures reveal that F11R dimers create trans-interactions between adjacent cells, stabil... |
| Subcellular Localization | </b></td><td>Plasma membrane (tight junctions)</td></tr> |
| Molecular Weight | 36 kDa |
| GeneCards | F11R |
| Human Protein Atlas | F11R |
| Extracellular Domain | Two immunoglobulin-like (Ig) domains that mediate homophilic (F11R-F11R) and heterophilic interactions |
| Transmembrane Domain | Single-pass α-helical transmembrane region |
| Cytoplasmic Tail | PDZ-binding motif that interacts with cytoskeletal proteins and signaling molecules |
| Inflammatory cytokines | TNF-α and IL-1β reduce F11R transcription |
| Oxidative stress | ROS disrupts F11R phosphorylation and localization |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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