| Gene Symbol | FERMITY |
| Aliases | Fermitin Family Member 2 |
| Function | Fermitin-2/Kindlin-2 performs essential functions: |
| Primary Expression | various tissues including the brain, where it regulates integrin-mediated signaling important for neuronal survival and [blood-brain barrier](/entitie |
| Subcellular Localization | </th><td>Plasma membrane, Cytoplasm, Focal adhesions</td></tr> |
| Molecular Weight | 76 kDa |
| Amino Acids | 683 aa |
| GeneCards | FERMITY |
| Human Protein Atlas | FERMITY |
| N-Terminal FERM Domain | Contains subdomains F1, F2, and F3 (4.1/ezrin/radixin/moesin homology) that mediate protein-protein and protein-lipid interactions |
| PH Domain | Pleckstrin homology domain for membrane localization through phosphoinositide binding |
| Proline-Rich Region | Contains binding sites for SH3 domain-containing proteins |
| Blood-Brain Barrier | Fermitin-2 in endothelial cells may regulate BBB integrity; variants could affect BBB dysfunction in AD<sup>[4]</sup> |
| Neuroinflammation | Modulates microglial adhesion and migration to sites of pathology |
| Synaptic Adhesion | Integrin-mediated adhesion at synapses; fermitin-2 may affect synaptic stability |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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