| Gene Symbol | FLOTILLIN1 |
| Aliases | FLOTILLIN1PROTEIN |
| Chromosome | 6p21.3. |
| Function | Flotillin-1 (also known as FLOT1) is a 47 kDa integral membrane protein that localizes to lipid rafts, specialized microdomains in the plasma membrane enriched in cholesterol and sphingolipids. |
| Subcellular Localization | </strong></td><td>Membrane rafts</td></tr> |
| GeneCards | FLOTILLIN1 |
| Human Protein Atlas | FLOTILLIN1 |
| Membrane Organization | Flotillin-1 generates and maintains lipid raft domains that serve as platforms for receptor signaling and membrane trafficking. |
| Signal Transduction | The protein scaffolds multiple signaling molecules including G proteins, kinases, and phosphatases, facilitating efficient signal propagation. |
| Protein Trafficking | Flotillin-1 regulates the endocytic and exocytic trafficking of membrane proteins including neurotransmitter receptors. |
| Synaptic Function | At synapses, flotillins regulate AMPA receptor recycling and NMDA receptor signaling, processes critical for synaptic plasticity[@flotillin2021]. |
| Amyloid Clearance | Studies show flotillin-1 can bind to Aβ peptides and may facilitate their clearance through endocytic pathways. |
| Neuronal Vulnerability | Lipid raft alterations in AD brains affect flotillin-1 distribution and function, potentially contributing to synaptic dysfunction. |
| Dopaminergic Signaling | Flotillin-1 regulates dopamine receptor trafficking and signaling in striatal neurons. Alterations in flotillin function may affect dopaminergic neurotransmission. |
| Mitochondrial Function | Emerging evidence suggests flotillin-1 interacts with mitochondrial proteins, potentially affecting neuronal energy metabolism in PD. |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |