protein 1,252 words KG: GBA2PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

GBA2 Protein - Non-lysosomal Glucosylceramidase

🔬 Protein Info
Gene SymbolGBA2
Full NameGlucosylceramidase Beta 2
AliasesPage for GBA2 Gene, Page for GBA2 Protein
Chromosome9q34.2
Protein FamilyGlycoside hydrolase family 31 (GH31)
Protein TypeEnzyme
FunctionGBA2 is a member of the glycoside hydrolase family 4.
Primary Expressionvarious tissues including brain, liver, and testis
Subcellular LocalizationEndoplasmic reticulum, plasma membrane, cytosol
Molecular Weight~95 kDa (846 amino acids)
Amino Acids846 aa
UniProt IDQ9HCG6
NCBI Gene ID57733
Ensembl IDENSG00000143633
GeneCardsGBA2
Human Protein AtlasGBA2
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Lysosomal Enzyme Trafficking Correction
Score: 0.49
Lysosomal Membrane Repair Enhancement
Score: 0.45
Sphingolipid Metabolism Reprogramming
Score: 0.44

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (15)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in