| Gene Symbol | Gem Nuclear Organelle Associated Protein 2 |
| Aliases | GEMIN2 gene in ALS and SMA |
| Chromosome | 14q13.2 |
| Function | is a critical component of the SMN (Survival of Motor Neuron) complex that is essential for spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis. |
| Subcellular Localization | ** | Nucleus (Cajal bodies), cytoplasm | |
| Gene Type | Protein coding |
| UniProt ID | O94876 |
| NCBI Gene ID | 25956 |
| Ensembl ID | ENSG00000145901 |
| OMIM | 609721 |
| N-terminal domain | Mediates interaction with SMN |
| Central alpha-helical region | Binds to SMN and other Gemin proteins |
| C-terminal region | Associates with snRNP-specific proteins |
| Alternative splicing regulation | The SMN complex is essential for neuronal-specific alternative splicing patterns |
| Synaptic function | snRNPs are required for expression of synaptic proteins |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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