protein 1,016 words KG: GIRK2 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

GIRK2/Kir2.2 — G Protein-Activated Inward Rectifier Potassium Channel 2

🔬 Protein Info
Gene SymbolGIRK2
Full NameGIRK2 (G Protein-Activated Inward Rectifier Potassium Channel 2)
AliasesG Protein-Activated Inward Rectifier Potassium Channel 2
Protein FamilyInward rectifier potassium channel (Kir2.x)
Protein TypeChannel
FunctionGIRK2 channels serve critical physiological roles
Primary Expressiondopaminergic neurons of the substantia nigra pars compacta (SNpc)
Subcellular LocalizationPlasma membrane, dendritic spines, axon terminals
Molecular Weight~50 kDa
UniProt IDP48051
GeneCardsGIRK2
Human Protein AtlasGIRK2
Protein NameGIRK2 (G Protein-Activated Inward Rectifier Potassium Channel 2)
GeneKCNJ6
PDB Structure7R0F, 7V6S
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Smartphone-Detected Motor Variability Correction
Score: 0.56
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in