| Gene Symbol | GLRBPROTEIN |
| Protein Type | Channel |
| Function | is a pentameric ion channel belonging to the Cys-loop receptor superfamily, which also includes GABA_A receptors and nicotinic acetylcholine receptors. |
| Primary Expression | the spinal cord and brainstem, where it participates in motor control, sensory processing, and reflex modulation |
| Molecular Weight | 55 kDa |
| Amino Acids | 495 aa |
| GeneCards | GLRBPROTEIN |
| Human Protein Atlas | GLRBPROTEIN |
| TM1 (221-244 amino acids) | Lines the channel pore and participates in gating |
| TM2 (245-266 amino acids) | Forms the ion channel pore; key residues determine chloride selectivity |
| TM3 (280-315 amino acids) | Contributes to the channel wall and allosteric coupling |
| TM4 (340-365 amino acids) | Forms the outermost helix and interacts with lipid environment |
| Motor control and coordination | Inhibitory interneurons modulate motor neuron activity |
| Sensory processing | Glycine receptor function in dorsal horn neurons modulates pain and touch sensations |
| Reflex arcs | Rapid inhibitory responses in spinal reflex pathways |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |