| Gene Symbol | GLUK2PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | **: Plasma membrane, postsynaptic density, presynaptic terminals |
| Molecular Weight | 100 kDa |
| GeneCards | GLUK2PROTEIN |
| Human Protein Atlas | GLUK2PROTEIN |
| Ligand-binding domain (LBD) | Two lobes (S1 and S2) that bind glutamate |
| Transmembrane domain (TMD) | Four helices (M1-M4) forming the ion channel pore |
| N-terminal domain (ATD) | Large extracellular domain involved in assembly and modulation |
| Fast synaptic transmission | Mediate EPSCs at some synapses |
| Presynaptic modulation | Regulate neurotransmitter release via presynaptic receptors |
| Neuronal development | Affect migration, axon guidance, and synapse formation |
| Pain transmission | Dorsal horn kainate receptors mediate nociception |
| Circadian rhythm | Involved in retinal signaling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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