| Gene Symbol | GLUR6PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the hippocampus, cerebral cortex, and cerebellum, where they play important roles in synaptic t |
| Amino Acids | 400 aa |
| GeneCards | GLUR6PROTEIN |
| Human Protein Atlas | GLUR6PROTEIN |
| Transmembrane domain (TMD) | Three transmembrane helices (M1, M3, M4) and a reentrant pore loop (M2) form the ion channel. The M2 pore loop determines ion selectivity and conductance properties. |
| Higher Ca2+ permeability | Unlike Q/R-edited AMPA receptors, GluR6 shows significant Ca2+ influx through the channel pore |
| Distinct pharmacological profile | Unique agonist and antagonist sensitivity compared to other kainate subunits |
| Multiple splice variants | Alternative splicing generates isoforms with distinct C-terminal tails and properties |
| Q/R RNA editing | The Q/R site is partially edited in humans (~60-80% depending on brain region), reducing Ca2+ permeability |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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