| Gene Symbol | GLUR7PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | to extrasynaptic sites ### Presynaptic Modulation GluR7 is predominantly found |
| GeneCards | GLUR7PROTEIN |
| Human Protein Atlas | GLUR7PROTEIN |
| Ligand-binding domain (LBD) | The S1S2 domain shows high-affinity glutamate binding with unique conformational properties that distinguish it from other GRIK subunits<sup>[1]</sup> |
| Transmembrane region | Four transmembrane helices (M1-M4) forming the ion channel pore |
| C-terminal tail | Contains a PDZ-binding motif (X-S/T-X-Φ) that enables interactions with synaptic scaffolding proteins |
| N-terminal domain | Contributes to receptor assembly and subunit specificity |
| GluR7a | Full-length variant widely expressed in the brain |
| GluR7b | Alternative C-terminus with altered trafficking properties |
| GluR7c | Variant with altered desensitization kinetics |
| High-affinity glutamate binding | Kd in the nanomolar range, similar to GluR8 |
| Partial agonist responses | Shows partial agonist activity for certain compounds |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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