| Gene Symbol | GLUR8PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | specific brain regions, playing important roles in synaptic transmission and circuit function |
| GeneCards | GLUR8PROTEIN |
| Human Protein Atlas | GLUR8PROTEIN |
| High-affinity glutamate binding domain | The ligand-binding domain (LBD) of GluR8 shows the highest affinity for glutamate among all kainate receptor subunits, with Kd values in the sub-micromolar range<sup>[1]</sup> |
| Distinct binding pocket | The ligand-binding pocket has unique amino acid residues that confer selective pharmacology compared to other GRIK subunits<sup>[1]</sup> |
| Transmembrane domain | Four transmembrane segments (M1-M4) that form the ion channel pore |
| C-terminal tail | Intracellular domain involved interactions and trafficking |
| Highest kainate affinity | GRIK4-containing receptors in protein bind kainate with the highest affinity among all kainate receptor configurations |
| LY382884 sensitivity | Particularly sensitive to the selective antagonist LY382884 |
| ATPA agonist | Responds uniquely to (2S,4R)-4-Phosphonomethyl-2-pyrrolidineacetic acid (ATPA), a GluR5-selective agonist |
| Concanavalin A modulation | Uniquely modulated by concanavalin A in some splice variants |
| GluR8a | Full-length variant with highest expression in the hippocampus |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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