| Gene Symbol | GRINC1 |
| Full Name | Glutamate Ionotropic Receptor NMDA Type Subunit 2C |
| Chromosome | 17q25.1 |
| Function | The GluN2C subunit forms functional NMDA receptors when assembled with the obligatory GluN1 subunit. |
| Primary Expression | Predominantly in cerebellar granule cells, olfactory bulb granule cells, thalamic relay neurons |
| UniProt ID | [Q9UQF2](https://www.uniprot.org/uniprot/Q9UQF2) |
| Ensembl ID | ENSG00000105409 |
| GeneCards | GRINC1 |
| Human Protein Atlas | GRINC1 |
| Biophysical properties | Moderate decay time, intermediate between GluN2A/B and GluN2D |
| Conductance | Lower single-channel conductance compared to GluN2A/B-containing receptors |
| Pharmacology | Sensitivity to ifenprodil (though less than GluN2B), selective agonists and antagonists |
| Epilepsy | Altered GRIN2C expression has been reported in some forms of epilepsy |
| Ataxia | Given its role in cerebellar function, GRIN2C may contribute to ataxic disorders |
| Schizophrenia | Some genetic association studies have suggested links to schizophrenia |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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