| Gene Symbol | GRK3PROTEIN |
| Protein Type | Kinase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the olfactory epithelium and: |
| Subcellular Localization | - **C-terminal tail**: Contains regulatory elements The RGS domain gives GRK3 u |
| Molecular Weight | 80 kDa |
| Amino Acids | 180 aa |
| GeneCards | GRK3PROTEIN |
| Human Protein Atlas | GRK3PROTEIN |
| Kinase domain | Catalytic domain with serine/threonine specificity |
| PH (Pleckstrin Homology) domain | At C-terminus, mediates membrane localization |
| C-terminal tail | Contains regulatory elements |
| β-arrestin recruitment | Phosphorylated receptors bind β-arrestin, blocking further G protein activation |
| Receptor internalization | β-arrestin-mediated endocytosis |
| Receptor downregulation | Lysosomal degradation or recycling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!