| Gene Symbol | GUCY2F |
| Aliases | retinal guanylate cyclase 2F, also known as ROS-GC1 or GUCYA3 |
| Function | The catalytic domain contains the signature residues required for GTP binding and cyclization. Dimerization (via the catalytic domains) is required for activity — GUCY2F functions as a homodimer, w... |
| Subcellular Localization | </td><td>Cone outer segment disc membranes</td></tr> |
| Molecular Weight | 120 kDa |
| Amino Acids | 100 aa |
| GeneCards | GUCY2F |
| Human Protein Atlas | GUCY2F |
| GCAP2 (GUCA2B) | Primary activator of GUCY2F in cones. At high Ca2+ (dark), GCAP2 is calcium-bound and inactive. At low Ca2+ (light), GCAP2 releases Ca2+ and undergoes conformational change, activating GUCY2F. |
| GCAP1 (GUCA2A) | Contributes to GUCY2F regulation in some cone types. |
| GCAP3 (GUCA2C) | Expressed in a subset of cones, may provide additional regulation. |
| Phenotype | Progressive loss of cone photoreceptor function, with relative preservation of rod function early in disease |
| Symptoms | Decreased visual acuity, impaired color vision (particularly red-green discrimination), photophobia, and sensitivity to light |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |