protein 632 words KG: HEXDC3 2026-03-13
kind:proteinsection:proteinsstate:published
Contents

HEXDC3

🔬 Protein Info
Gene SymbolHDDX3
Full NameHEXDC3
AliasesHEXA [@platt2020]
Chromosome15q24.2 [@conway2004]
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localizationboth cytoplasmic and potentially nuclear compartments, though subcellular distribution may vary depending on post-transl
Amino Acids529 aa
Exons14
UniProt IDSearch UniProt
NCBI Gene ID284161
Ensembl IDENSG00000146243
GeneCardsHDDX3
Human Protein AtlasHDDX3
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in