| Gene Symbol | HIP2 |
| Aliases | Huntingtin Interacting Protein 2 |
| Protein Type | Enzyme |
| Function | The FIC domain catalyzes the transfer of AMP from ATP to target proteins (AMPylation), a reversible post-translational modification that regulates chaperone function. |
| Subcellular Localization | </strong> Endoplasmic reticulum lumen</li> <li><strong>PDB:</strong> [6BG1](http |
| Molecular Weight | 52 kDa |
| GeneCards | HIP2 |
| Human Protein Atlas | HIP2 |
| N-terminal ER-targeting signal sequence | directs the protein to the ER lumen |
| Transmembrane domain | anchors the protein to the ER membrane with the catalytic domain in the ER lumen |
| TPR-like domain | mediates protein-protein interactions |
| Huntingtin binding | HIP2 binds to the N-terminal region of huntingtin |
| Proteasome regulation | HIP2 also interacts with the 26S proteasome, potentially linking HD pathology to impaired protein degradation |
| ER stress in HD | Expanded huntingtin causes ER stress, and HIP2 dysfunction may exacerbate this |
| Alzheimer's disease | Chronic ER stress contributes to Aβ toxicity and tau pathology |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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