| Gene Symbol | HSP70PROTEINFAMILY |
| Aliases | HSP70PROTEINFAMILY |
| Function | ### Domain Architecture |
| Subcellular Localization | </strong></td><td>Cytoplasm, ER (BiP/GRP78), mitochondria, nucleus</td></tr> |
| HSPA1A/Hsp70-1 | Stress-inducible Hsp70, major heat shock protein |
| HSPA1B/Hsp70-2 | Highly similar to HSPA1A, co-expressed |
| HSPA2/Hsp70-2 | Testis-specific, involved in spermatogenesis |
| HSPA5/GRP78/BiP | Endoplasmic reticulum resident, essential for ER function |
| HSPA8/HSC70 | Constitutively expressed, involved in autophagy |
| HSPA9/GRP75/mtHsp75 | Mitochondrial Hsp70, mitochondrial protein import |
| HSPA14/LAP | Lysosome-associated Hsp70 |
| ATPase domain | Belongs to the actin-Hsp70 superfamily, undergoes large conformational changes |
| Lateral pore | Allows substrate entry into SBD |
| Allosteric coupling | ATP hydrolysis in N-domain triggers conformational changes in C-domain |
| EEVD motif | C-terminal sequence (EEVD) for co-chaperone binding |
| Substrate-binding pocket | Hydrophobic residues recognizeunstructured protein regions |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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