| Gene Symbol | HTR1BPROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ** | Plasma membrane, presynaptic terminals | |
| Molecular Weight | 50 kDa |
| GeneCards | HTR1BPROTEIN |
| Human Protein Atlas | HTR1BPROTEIN |
| N-terminal extracellular domain | Contains glycosylation sites |
| Transmembrane helices (TM1-TM7) | Form the ligand-binding pocket |
| Cysteine-rich disulfide bond | Between ECL1 and ECL2 for structural stability |
| Differential splicing | Generates multiple receptor isoforms |
| Presynaptic autoreceptor | Located on serotonin neuron terminals, inhibits further 5-HT release |
| Presynaptic heteroreceptor | Modulates glutamate, GABA, and dopamine release |
| Migraine pathophysiology | Trigeminovascular activation involves HTR1B |
| Aggression and mood | Prefrontal cortex expression affects aggressive behavior |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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