| Gene Symbol | IKBALPHA |
| Function | IκBα (Inhibitor of NF-κB α, encoded by NFKBIA) is the prototypical member of the IκB family of proteins, serving as the primary cytoplasmic inhibitor of the NF-κB transcription factor. |
| Primary Expression | Ubiquitous, inducible |
| Subcellular Localization | signals |
| Molecular Weight | 36 kDa |
| Amino Acids | 317 aa |
| GeneCards | IKBALPHA |
| Human Protein Atlas | IKBALPHA |
| Interactor | Relationship |
| [NF-κB (RELA/p50 dimer)](/entities/nf-kb) | Direct binding |
| IKK complex | Substrate of |
| β-TrCP (FBXW11) | E3 ligase |
| 26S Proteasome | Degradation target |
| [HDAC1/2/3](/entities/histone-deacetylases) | Co-repressor complex |
| Gene | NFKBIA |
| Associated Diseases | neurodegeneration |
| Interactions | IL-1Β, IL-6, IL-8, MAPK, HO-1, NF-ΚB |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |