| Gene Symbol | IKKALPHA |
| Protein Type | Protein |
| Function | is a cytoplasmic inhibitory protein that functions as a critical negative regulator of the nuclear factor-kappa B (NF-κB) signaling pathway. |
| Molecular Weight | 36 kDa |
| Pathways | NF-κB |
| UniProt ID | Search UniProt |
| GeneCards | IKKALPHA |
| Human Protein Atlas | IKKALPHA |
| Ankyrin Repeat Domain | Six tandem ankyrin repeats (residues 1-183) constitute the primary NF-κB binding interface, providing high-affinity interaction with NF-κB p65/p50 heterodimers[^2] |
| Signal-Responsive Domain (SRD) | Located at the N-terminus (residues 1-70), this region contains two conserved serine residues (Ser32 and Ser36) that are phosphorylation targets for the IκB kinase (IKK) complex |
| Nuclear Localization Signals (NLS) | Enable IκBα to enter the nucleus and bind to NF-κB already present in nuclear compartments[^3] |
| Degron Sequences | Phosphorylation-dependent ubiquitination sites that target IκBα for 26S proteasomal degradation following IKK-mediated phosphorylation |
| C-Terminal PEST Domain | Rich in proline, glutamic acid, serine, and threonine residues; contributes to protein instability and rapid turnover[^4] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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