| Gene Symbol | KCNK15 |
| Aliases | KCNK15PROTEIN |
| Function | KCNK15 belongs to the K2P channel family, characterized by a unique architecture distinct from all other potassium channel families. |
| Subcellular Localization | </strong></td><td>Plasma membrane</td></tr> |
| GeneCards | KCNK15 |
| Human Protein Atlas | KCNK15 |
| Resting potential maintenance | KCNK15 contributes to setting the resting membrane potential at the hyperpolarized end of the physiological range |
| Excitability threshold | By stabilizing the resting potential, KCNK15 influences the threshold for action potential generation |
| Preventing hyperexcitability | Adequate KCNK15 function counteracts hyperexcitability that can lead to excitotoxicity |
| Synaptic integration | Leak conductance affects the time constant of the neuron, influencing how synaptic inputs are temporally integrated |
| Hypoxia activation | KCNK15 is activated by low oxygen conditions, hyperpolarizing neurons to reduce energy expenditure |
| Ischemia response | During metabolic compromise, KCNK15 activity increases to reduce calcium influx through voltage-gated calcium channels |
| ATP conservation | By hyperpolarizing neurons, KCNK15 reduces the activity of the Na⁺/K⁺-ATPase, conserving limited ATP stores |
| Glutamate reduction | Reduced neuronal activity decreases glutamate release from presynaptic terminals, preventing excitotoxic injury |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |