| Gene Symbol | KCNK16 |
| Aliases | KCNK16PROTEIN |
| Function | KCNK16 (Potassium Two Pore Domain Channel Subfamily K Member 16), also known as TASK-5 or TALK-1, is a member of the two-pore domain (K2P) potassium channel family. |
| Subcellular Localization | </strong></td><td>Cell membrane</td></tr> [@cook2003] |
| Molecular Weight | 38 kDa |
| GeneCards | KCNK16 |
| Human Protein Atlas | KCNK16 |
| N-terminus | Intracellular domain involved in channel trafficking and regulation by intracellular signals |
| Transmembrane segments | Four alpha-helices (M1-M4) that span the lipid bilayer |
| Pore domains | Two selectivity filter regions (P1 and P2) conferring K+ selectivity |
| C-terminus | Intracellular regulatory domain with potential interaction sites |
| Basal potassium permeability | Maintains the resting membrane potential of acinar cells |
| Fluid secretion | Couples potassium efflux to chloride and water movement |
| Saliva composition | Influences final ionic composition of saliva |
| Pancreatic duct bicarbonate secretion | Contributes to alkalinization of pancreatic juice |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |